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Monday, April 20, 2020 | History

3 edition of Cellular and Molecular Physiology of Sodium-Calcium Exchange found in the catalog.

Cellular and Molecular Physiology of Sodium-Calcium Exchange

Proceedings of the Fourth International Conference (Annals of the New York Academy of Sciences, V. 976)

by Jonathan Lytton

  • 319 Want to read
  • 14 Currently reading

Published by New York Academy of Sciences .
Written in English

    Subjects:
  • Cellular biology,
  • Life Sciences - Cytology,
  • Science,
  • Calcium channels,
  • Congresses,
  • Ion Transport,
  • Sodium channels,
  • Sodium cotransport systems,
  • Science/Mathematics

  • The Physical Object
    FormatPaperback
    Number of Pages549
    ID Numbers
    Open LibraryOL12228583M
    ISBN 101573313874
    ISBN 109781573313872

    Sodium/calcium exchange: its physiological implications. Physiol Rev 79 Link ISI Google Scholar; 4 Blaustein MP, Santiago EM. Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons. Biophys J 20 Crossref PubMed ISI Google Scholar; 5 Catterall by: 7. The ion exchange mechanism of the sodium/calcium exchanger (NCX) crystallized by Liao et al. in is studied using the Poisson–Fermi theory developed by Liu and Eisenberg in A cycle of binding and unbinding is proposed to account for the Na+/Ca2+ exchange function of the NCX molecule. Outputs of the theory include electric and steric fields of ions with different sizes, correlations. From Neuron to Brain - Text Only - 5th edition. ISBN Transport across Cell Membranes The Sodium-Potassium Exchange Pump Calcium Pumps Sodium-Calcium Exchange Chloride Transport Transport of Neurotransmitters Molecular Structure of Transporters Significance of Transport Mechanisms Properties of Neurons and Glia 5 Book Edition: 5th


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Cellular and Molecular Physiology of Sodium-Calcium Exchange by Jonathan Lytton Download PDF EPUB FB2

Get this from a library. Cellular and molecular physiology of sodium-calcium exchange: proceedings of the fourth international conference. [Jonathan Lytton; American Physiological Society ();]. ISBN: OCLC Number: Notes: The result of a conference entitled: Cellular and Molecular Physiology of Sodium-Calcium Exchange: The IVth International Conference, sponsored by the American Physiological Society and Cellular and Molecular Physiology of Sodium-Calcium Exchange book on Octoberin Banff, Alberta, Canada.

Plasma membrane Na-Ca exchange is an essential component of Ca signaling pathways in several tissues. Activity is especially high in the heart where the exchanger is an important regulator of contractility.

An expanding exchanger superfamily includes three mammalian Na-Ca exchanger genes and a number of alternative splicing products. New information indicates that the exchanger protein Cited by: Intracellular calcium concentrations in both cardiac and vascular smooth muscle cells range from to M.

Extracellular concentration of calcium is about 2 × M (2 mM). Therefore, there is a chemical gradient for calcium to diffuse into the cell. Description Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes.

This volume, which is the proceedings of the fifth in a series of international conferences, includes contributions that merge molecular biology, biochemistry, biophysics, and physiology, providing novel insights that significantly advance our understanding.

Cellular and Molecular Physiology of Sodium-Calcium Exchange book present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca 2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Manufacturer: Springer.

Sodium/calcium exchange: its physiological implications. Blaustein MP(1), Lederer WJ. Author information: (1)Departments of Physiology, University of Maryland School of Medicine, Baltimore, USA. The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal by: Apart from non-regulated leakage, there are only two routes by which Cellular and Molecular Physiology of Sodium-Calcium Exchange book can leave the smooth muscle cell; via Ca-ATPase and via sodium/calcium exchange.

As these mechanisms have been the subject of recent reviews, only a short overview will be given here [36, 37, 63, 64]. The plasma membrane Ca-ATPase, PMCA, is a P-type enzyme with four.

Cellular Physiology. Sodium/Calcium Exchange: Its Physiological Implications. Article. Early studies suggested that these molecular motors work by very different mechanisms.

Recently. Kenneth J. Smith Ph.D., in Multiple Sclerosis As A Neuronal Disease, IX. NO and the Sodium-Calcium Exchanger. The axolemmal sodium-calcium exchanger is a non-ATP-dependent antiporter that normally functions to export calcium ions from the axon at the expense of importing sodium ions. There is evidence that under pathological circumstances, the exchanger can sometimes operate in reverse.

The sodium-calcium exchanger (often denoted Na + /Ca 2+ exchanger, exchange protein, or NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the Cellular and Molecular Physiology of Sodium-Calcium Exchange book gradient of sodium (Na +) by allowing Na + to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca 2+).HGNC: Hormones and other extra-cellular agents bring about many of their effects by causing changes in intra-cellular calcium concentration.

This book provides a comprehensive description of current techniques for measuring intra-cellular calcium concentrations, including protocols for the use of fluorescent, bioluminescent and metallochromic. This book reports the text of the lectures of the 6 th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia Cellular and Molecular Physiology of Sodium-Calcium Exchange book the Gulf of Naples, Italy, from October 1 to October 5, The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the.

Mordecai P. Blaustein’s most popular book is Cellular Physiology. Books by Mordecai P. Blaustein. Mordecai P. Blaustein Average rating 9 ratings 1 reviews shelved 25 times Cellular And Molecular Physiology Of Sodium Calcium Exchange.

Author(s): Lytton,Jonathan Title(s): Cellular and molecular physiology of sodium-calcium exchange: proceedings of the fourth international conference/ edited by Jonathan Lytton. Calcium ions (Ca 2+) contribute to the physiology and biochemistry of organisms play an important role in signal transduction pathways, where they act as a second messenger, in neurotransmitter release from neurons, in contraction of all muscle cell types, and in enzymes require calcium ions as a cofactor, including several of the coagulation factors.

| Phys. Chem. Chem. Phys.,17, This ournal is ' the Owner Societies Cite this, 17, Energetics of sodium–calcium exchanged zeolite A H.

Sun,a D. Wu,b X. Guo,b B. Shena and A. Navrotsky*b A series of calcium-exchanged zeolite A samples with different degrees of exchange were prepared.

Abstract. The Na + /Ca 2+ exchange system in plasma membrane plays a key role in the extrusion of cellular Ca 2+ and the regulation of intracellular Ca 2+ concentration in many tissues.

1 In the kidney, support for the presence of a Na + /Ca 2+ exchange system comes from findings that showed removal of Na + from peritubular fluid in the microperfused tubules inhibits Ca 2+ transport, 2 and Author: C.

Liang, H. Hanai, L. Cheng, J. Barnes, B. Sacktor. The influence of external cations on the rate at which a Ca2+ load was eliminated in exchange for external Na+ was studied by measuring the inward current associated with Na+‐Ca2+ exchange in sa The effect of ions on sodium‐calcium exchange in salamander by: The carbohydrates, lipids, and proteins in the foods you eat are used for energy to power molecular, cellular, and organ system activities.

Importantly, the energy is stored primarily as fats. The quantity and quality of food that is ingested, digested, and absorbed affects the amount of fat that is stored as excess calories.

Diet—both what. Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A. American journal of physiology Lung cellular and molecular physiology. ; (10): L PMCID: Sathish V, Abcejo AJ, Thompson MA, Sieck GC, Prakash YS, Pabelick CM.

Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle. Cellular Physiology: Mosby's Physiology Monograph Series (Mosby's Physiology Monograph) Mordecai P.

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The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Brand: Springer US.

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Blaustein, Joseph PY Kao, and Donald R. Matteson. The expanded and thoroughly updated content in this Mosby Physiology Monograph Series title bridges the gap between basic biochemistry, molecular and cell biology, neuroscience, and organ and systems.

Sodium–calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations Jason Urbanczyk Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences, South Orange Avenue, Newark, NJ ‐, USACited by: Fluid, Electrolyte, and Acid-Base Balance.

Name the disorders associated with abnormally high and low levels of the six electrolytes. The body contains a large variety of ions, or electrolytes, which perform a variety of functions.

Some ions assist in the transmission of electrical impulses along cell membranes in neurons and muscles. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca 2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels.

Cellular and molecular physiology of sodium-calcium exchange: proceedings of the fourth international conference. Proc. Acad.

Sci. ; 1 View in ArticleCited by: Smlium-Cnicium Exchange--Edited by T. ALLEN, D. NOaLE and H. REUTER pp. Oxford University Press, Oxford. $ This book is dedicated to the memory of Peter Baker who played a key role in the discovery and study of sodium-calcium exchange (E).

Three sodium ions from inside the cell first bind to the transport protein. A phosphate group is transferred from ATP to the transport protein causing it to change shape and. Plasmalemmal sodium-calcium exchanger shapes the calcium and exocytotic signals of chromaffin cells at physiological temperature.

Cultural Psychology and the Problem of Exchange between Individual and Environment: Is There a Common Concept. American Journal of Physiology-Lung Cellular and Molecular Physiology; American Journal of Cited by: The Na + /Ca 2+ exchanger is the major Ca 2+ extrusion mechanism in cardiac myocytes.

The activity of the cardiac Na + /Ca 2+ exchanger is dynamically regulated by intracellular Ca 2+.Previous studies indicate that Ca 2+ binding to a high-affinity Ca 2+-binding domain (CBD1) in the large intracellular loop is involved in generated transgenic zebrafish with cardiac-specific Cited by:   Allosteric Activation of Sodium–Calcium Exchange Activity by Calcium Allosteric Activation of Sodium–Calcium Exchange Activity by Calcium Reeves, John P.; Condrescu, Madalina The activity of the cardiac Na + /Ca 2+ exchanger is stimulated allosterically by Ca 2+, but estimates of the half-maximal activating concentration have varied over a wide range.

Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes.

This volume, which is the proceedings of the fifth in a series of international conferences, includes contributions that merge molecular biology, biochemistry, biophysics, and physiology, providing novel insights that.

Parathyroid hormone increases sodium/calcium exchange activity in renal cells and the blunting of the response in aging Article (PDF Available) in Journal of Biological Chemistry (12) Background-Sarcolemmal Na/Ca exchange (NCX) regulates cardiac Ca and contractility.

NCX function during the cardiac cycle is determined by intracellular [Ca] and [Na] ([Ca] i, and [Na] i) and membrane potential (E m), which all change in human heart failure (HF).Therefore, changes in NCX function may contribute to abnormal Ca regulation in human by:   The expression of NCX2 along intra-epidermal nerve terminals provides a molecular substrate for sodium-calcium exchange in these fibers.

NCX is known to be present along the trunks of myelinated axons [ 16 ] where, under normal (non-pathological) conditions, sodium-calcium exchange is coupled to sodium influx, and contributes to calcium Cited by: The Sodium--Potassium Exchange Pump Calcium Pumps Sodium--Calcium Exchange Chloride Transport Transport of Neurotransmitters Molecular Structure of Transporters Significance of Transport Mechanisms Properties of Neurons and Glia 5.

Ionic Basis of the Resting Potential A Model Cell Membrane Potentials in Squid Axons Changes in Membrane Potential Edition: 4th The carbohydrates, lipids, and proteins in the foods you eat are used for energy to power molecular, cellular, and organ system activities.

Importantly, the energy is stored primarily as fats. The quantity and quality of food that is ingested, digested, and absorbed affects the. Sodium/calcium exchanger is found as the ATP dependent antiporter which mainly plays its role in pdf calcium ions and importing sodium ions.

Explanation of Solution In the cardiac muscle cells, the sodium and calcium exchangers actasa secondary active transporter because it mainly uses the electrochemical gradient of sodium across the.The myocardium is highly organized tissue, composed of several cell types download pdf include smooth muscle cells, fibroblasts, and cardiac myocytes.

The fundamental contractile cell of the myocardium is the myocyte. The purpose of this review is to examine the structural components of the myocyte and then to place these components into a functional context with respect to the contractile by:   The calcium phosphate‐based skeleton ebook vertebrates serves as the major reservoir for metabolically available calcium ions.

The skeleton ebook formed by osteoblasts which first secrete a proteinaceous matrix and then provide Ca ++ for the calcification process. The two calcium efflux ports found in most cells are the plasma membrane Ca‐ATPase (PMCA) and the sodium–calcium .